MicroRNAs in Angiogenesis and Vascular Smooth Muscle Cell Function
نویسندگان
چکیده
منابع مشابه
MicroRNAs in angiogenesis and vascular smooth muscle cell function.
The Human Genome Project was barely completed in 2003 before a new quest was launched: this time, in a search for short stretches of RNA called microRNA. The belief that these miniature molecules, which had only been discovered a decade earlier, were major regulators of genetic function gained momentum in the intervening years and sparked a worldwide interest in the physiologic and pathologic r...
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In view of the bioinformatic projection that a third of all protein coding genes and essentially all biological pathways are under control of microRNAs (miRNAs), it is not surprising that this class of small RNAs plays roles in vascular disease progression. MiRNAs have been shown to be involved in cholesterol turnover, thrombosis, glucose homeostasis and vascular function. Some miRNAs appear to...
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The control of force production in vascular smooth muscle is critical to the normal regulation of blood flow and pressure, and altered regulation is common to diseases such as hypertension, heart failure, and ischemia. A great deal has been learned about imbalances in vasoconstrictor and vasodilator signals, e.g., angiotensin, endothelin, norepinephrine, and nitric oxide, that regulate vascular...
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Although smooth muscle cells participate in the remodeling associated with atherosclerosis and other vascular diseases, the mechanisms by which these cells interact with their mechanical environment are incompletely characterized. This thesis serves to elucidate the capacity of smooth muscle cells to modulate their matrix and respond to mechanical loading. Because integrins mediate many cell-ma...
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Vascular smooth muscle cells (VSMCs) undergo two important physiological processes such as differentiation (contractile state) and dedifferentiation (proliferative state) during vascular diseases. In general, a prerequisite for pathological and physiological vascular remodeling processes such as atherosclerosis, hypertension, and restenosis after angioplasty is the phenotype alteration of VSMCs...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2010
ISSN: 0009-7330,1524-4571
DOI: 10.1161/res.0b013e3181d61a0d